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New bioRxiv paper in collaboration with Sossin lab; stalled polysomes in neurons
Local translation in neurons is mediated in part by the reactivation of stalled polysomes. However, the mechanism for stalling of the polysomes is not understood.
https://www.biorxiv.org/content/10.1101/2021.02.22.432349v1.full.pdf
Electron micrograph of negatively stained pellet preparation from rat brain, containing compacted stalled polysomes from Anadolu et al. bioRxiv https://doi.org/10.1101/2021.02.22.432349.
The data supports a model in which specific sequences in mRNAs act to stall translation elongation in neurons, attracting FMRP and beginning a process where stalled ribosomes are packaged and transported in RNA granules.