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New bioRxiv paper in collaboration with Sossin lab; stalled polysomes in neurons

Local translation in neurons is mediated in part by the reactivation of stalled polysomes. However, the mechanism for stalling of the polysomes is not understood.


Electron micrograph of negatively stained pellet preparation from rat brain, containing compacted stalled polysomes from Anadolu et al. bioRxiv https://doi.org/10.1101/2021.02.22.432349.

The data supports a model in which specific sequences in mRNAs act to stall translation elongation in neurons, attracting FMRP and beginning a process where stalled ribosomes are packaged and transported in RNA granules.