Proteins catalyse most of the reactions in the cell on which life depends. Translational control is defined as a change in protein production per mRNA per unit of time, and it is a powerful means to alter protein abundance. Our lab is particularly interested in understanding the molecular and signalling mechanisms of translational control in the brain and how they control complex brain functions and behaviours, such as learning, memory, social interactions, anxiety and fear.
The complex polygenic nature of neurodevelopmental disorders (NDs) along with the plethora of contributing non-genetic factors have impeded our efforts to understand and treat NDs.
By studying converging signalling, molecular and cellular pathways, we can shed fresh light on the causality of NDs.
Elucidating complex brain functions is key for designing novel therapeutics for NDs.
Using biochemical, electrophysiological and behavioural analysis in rodents, we wish to examine translational control as a key tenet in the pathophysiology of neuropsychiatric/ neurodevelopmental disorders such as Autism Spectrum Disorders (ASD), Fragile X Syndrome (FXS) and Intellectual Disability (ID).