2023

Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N*, Gkogkas CG*, Khoutorsky A*. Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron 2023

doi: 10.1016/j.neuron.2023.06.017 *co-last author

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Chalkiadaki K., Statoulla E., Zafeiri M., Haji N., Lacaille J.C., Powell C.M., Jafarnejad S.M., Khoutorsky A., Gkogkas C. G. Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1. Front Cell Dev Biol 2023

doi: 10.3389/fcell.2023.1205112

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Patil S, Chalkiadaki K, Mergiya TF,  Krimbacher K, Amorim IS, Akerkar S, Gkogkas CG*, Bramham CR*. eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience 2023

https://doi.org/10.1016/j.isci.2023.106649 *co-last author

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Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS. Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association. J Neurosci. 2023

doi: 10.1523/JNEUROSCI.1002-22.2023

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2022

Chalkiadaki K., Hooshmandi M., Lach G., Statoulla E., SImburiger S., Amorim I.S., Kouloulia S., Zafeiri M., Pothos P., Bonneil E., Gantois I., Popic J., Kim S.H., Wong C., Cao R., Komiyama N., Atlasi Y., Jafarnejad S.M., Khoutorsky A. and Gkogkas C.G. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain 2022

https://doi.org/10.1093/brain/awac398

​

Roque PS, Thörn Perez C, Hooshmandi M, Wong C, Eslamizade MJ, Heshmati S, Brown N, Sharma V, Lister KC, Goyon VM, Neagu-Lund LE, Shen C, Daccache N, Sato H, Sato T, Mogil JS, Nader K, Gkogkas CG, Iordanova MD, Prager-Khoutorsky M, McBride HM, Lacaille JC, Wykes L, Schricker T, Khoutorsky A. Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice. J Clin Invest. 2022 

https://doi: 10.1172/JCI159344.

​

Patil S., Chalkiadaki K., Mergiya-Feissa T., SImbriger K., Amorim I. S., Akerkar S. Gkogkas C. G.*, Bramham C. R.* eIF4E phosphorylation recruits β-catenin to mRNA cap and selectively promotes Wnt pathway translation in dentate gyrus LTP maintenance in vivo. bioRxiv 2022 doi:10.1101/2022.09.28.509312 *co-last author

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Anadolu M.N., Sun J., Kailasam S., Simbriger K., Markova T., Jafarnejad S.M., Lefebvre F., Ortega J., Gkogkas C.G., Sossin W.S. Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association bioRxiv, 2021.02. 22.432349

doi: https://doi.org/10.1101/2021.02.22.432349

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Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister K, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A. Microglia-mediated degradation of perineuronal nets promotes pain. Science. 2022 May 26:eabl6773. doi: 10.1126/science.abl6773. 
 

Liu D, Nanclares C, Simbriger K, Fang K, Lorsung E, Le N, Amorim IS, Chalkiadaki K, Pathak SS, Li J, Gewirtz JC, Jin VX, Kofuji P, Araque A, Orr HT, Gkogkas CG*, Cao R*. Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition. Mol Psychiatry. 2022 Mar 17. doi: 10.1038/s41380-022-01499-6. *co-last author/co-corresponding

2021
Statoulla E, Chalkiadaki K, Karozis D, Gkogkas CG. Regulation of mRNA translation in stem cells; links to brain disorders. Cell Signal. 2021 Dec;88:110166. doi: 10.1016/j.cellsig.2021.110166.

Chalkiadaki K, Statoulla E, Markou M, Bellou S, Bagli E, Fotsis T, Murphy C, Gkogkas CG. Translational control in neurovascular brain development. R Soc Open Sci. 2021 Oct 13;8(10):211088. doi: 10.1098/rsos.211088.

Roque PS, Hooshmandi M, Neagu-Lund L, Yin S, Yousefpour N, Sato H, Sato T, Nakadate Y, Kawakami A, Tahmasebi S, Ribeiro-da-Silva A, Gkogkas CG, Prager-Khoutorsky M, Schricker T, Wykes L, Khoutorsky A. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Sci Rep. 2021 Jul 29;11(1):15490. doi: 10.1038/s41598-021-94849-3.

Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, Watt AJ, Gkogkas CG*, Khoutorsky A*. 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Reports. 2021 Apr 27;35(4):109036. doi: 10.1016/j.celrep.2021.109036 (2021) *co-last author/co-corresponding

Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM, Khoutorsky A and Gkogkas CG. Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Prog Neurobiol. 2020 Aug 26:101903. doi: 10.1016/j.pneurobio.2020.101903. (2021)

2020
Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A and Gkogkas CG. Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods. 2020 Jan 1;329:108456. doi: 10.1016/j.jneumeth.2019.108456. Epub 2019 Oct 11. (2020)

Atlasi Y, Jafarnejad SM, Gkogkas CG, Vermeulen M, Sonenberg N, Stunnenberg HG. The translational landscape of ground state pluripotency. Nat Commun. 2020 Apr 1;11(1):1617. doi: 10.1038/s41467-020-15449-9. (2020)

2019
Hoang HD, Graber TE, Jia JJ, Vaidya N, Gilchrist VH, Xiang X, Li W, Cowan KN, Gkogkas CG, Jaramillo M, Jafarnejad SM, Alain T. Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Rep. Dec 17;29(12):4010-4023.e5. doi: 10.1016/j.celrep.2019.11.072. (2019)

Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A and Gkogkas CG. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep. 2019 Dec 10;29(11):3620-3635.e7. doi: 10.1016/j.celrep.2019.11.023. (2019)

2018
Amorim IS, Lach G and Gkogkas CG. 
The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders. Front Genet. 2018 Nov 23;9:561. doi: 10.3389/fgene.2018.00561. eCollection (2018).

Uttam, S., Wong, C, Amorim, I. S., Jafarnejad, S. M., Tansley, S., Yang, J., Prager-Khoutorsky, M., Mogil, J. S., Gkogkas, C. G.* and Khoutorsky, A.* Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of pain Aug-Dec;4:35-44. doi: 10.1016/j.ynpai.2018.04.001. Epub 2018 Apr 18. (2018) *co-last author/co-corresponding

Amorim I.S., Kedia S., Kouloulia S., Simbriger K., Gantois I., Jafarnejad S. M., Li Y., Kampaite A., Pooters T., Romanò N and Gkogkas C.G. Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation. The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 38(8):2118-2133. doi: 10.1523/JNEUROSCI.2673-17.2018 (2018).

Jafarnejad, S. M., Chapat, C., Matta-Camacho, E., Gelbart, I. A., Hesketh, G. G., Arguello, M., Garzia, A., Kim, S. H., Attig, J., Shapiro, M., Morita, M., Khoutorsky, A., Alain, T., Gkogkas, C., Stern-Ginossar, N., Tuschl, T., Gingras, A. C., Duchaine, T. F. & Sonenberg, N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife 7, doi:10.7554/eLife.35034 (2018).

2017
Martin, L. J., Smith, S. B., Khoutorsky, A., Magnussen, C. A., Samoshkin, A., Sorge, R. E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, T. M., Mir, E., Gibson, D. G., Wieskopf, J. S., Sotocinal, S. G., Austin, J. S., Meloto, C. B., Gitt, J. H., Gkogkas, C., Sonenberg, N., Greenspan, J. D., Fillingim, R. B., Ohrbach, R., Slade, G. D., Knott, C., Dubner, R., Nackley, A. G., Ribeiro-da-Silva, A., Neely, G. G., Maixner, W., Zaykin, D. V., Mogil, J. S. & Diatchenko, L. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest 127, 3353-3366, doi:10.1172/JCI87406 (2017).

Moy, J. K., Khoutorsky, A., Asiedu, M. N., Black, B. J., Kuhn, J. L., Barragan-Iglesias, P., Megat, S., Burton, M. D., Burgos-Vega, C. C., Melemedjian, O. K., Boitano, S., Vagner, J., Gkogkas, C. G., Pancrazio, J. J., Mogil, J. S., Dussor, G., Sonenberg, N. & Price, T. J. The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 7481-7499, doi:10.1523/JNEUROSCI.0220-17.2017 (2017).

Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, V. T., Wiebe, S., Groves, I. A., Jafarnejad, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J. C., Gkogkas, C. G.* & Sonenberg, N.* Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature Medicine 23, 674-677, doi:10.1038/nm.4335 (2017). *co-last author

Chapat, C., Jafarnejad, S. M., Matta-Camacho, E., Hesketh, G. G., Gelbart, I. A., Attig, J., Gkogkas, C. G., Alain, T., Stern-Ginossar, N., Fabian, M. R., Gingras, A. C., Duchaine, T. F. & Sonenberg, N. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America 114, 5425-5430, doi:10.1073/pnas.1701488114 (2017).

Tuttle, A. H., Tansley, S., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O. M., Yachnin, D., Austin, J. S., Chan, C. M., Pooters, T., Groves, I., Martin, L. J., Sonenberg, N., Gkogkas, C. G.* & Mogil, J. S.* Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America 114, 5515-5520, doi:10.1073/pnas.1703477114 (2017). *co-last author

2016
Tahmasebi S., Jafarnejad S. M., Tam I. S., Gonatopoulos-Pournatzis T., Matta-Camacho E., Tsukumo Y., Yanagiya A., Li W., Atlasi Y., Caron M., Braunschweig U., Pearl D., Khoutorsky A., Gkogkas C. G., Nadon R., Bourque G., Yang X. J., Tian B., Stunnenberg H. G., Yamanaka Y., Blencowe B. J., Giguère V., & Sonenberg N. Control of embryonic stem cells self-renewal and differentiation via coordinated splicing and translation of YY2. PNAS doi: 10.1073/pnas.1615540113 (2016)
 
Khoutorsky, A., Sorge R.E., Prager-Khoutorsky M., Pawlowski S. A., Longod G., Jafarnejad S. M., Tahmasebi S., Martin L., Pitchere M. H., Gkogkas C. G., Sharif-Naeinig R., Alfredo Ribeiro-da-Silvad A., Bourque C. W., Cerveroh F., Mogil J. S., & Sonenberg N. eIF2alpha phosphorylation controls thermal nociception. PNAS doi: 10.1073/pnas.1614047113 (2016)
 
Skalecka, A., Liszewska, E., Bilinski, R., Gkogkas, C., Khoutorsky, A., Malik, A. R., Sonenberg, N. & Jaworski, J. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Dev Neurobiol doi:10.1002/dneu.22392 (2016).
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2015
Khoutorsky, A., Bonin, R. P., Sorge, R. E., Gkogkas, C. G., Pawlowski, S. A., Jafarnejad, S. M., Pitcher, M. H., Alain, T., Perez-Sanchez, J., Salter, E. W., Martin, L., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J. S. & Sonenberg, N. Translational control of nociception via 4E-binding protein 1. Elife 4, doi:10.7554/eLife.12002 (2015).
 
Maity, S., Rah, S., Sonenberg, N., Gkogkas, C. G. & Nguyen, P. V. Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learn Mem 22, 499-508, doi:10.1101/lm.039222.115 (2015).
 
Aguilar-Valles, A., Matta-Camacho, E., Khoutorsky, A., Gkogkas, C., Nader, K., Lacaille, J. C. & Sonenberg, N. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 11125-11132, doi:10.1523/JNEUROSCI.4615-14.2015 (2015).
 
Cao, R., Gkogkas, C. G., de Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18, 855-862, doi:10.1038/nn.4010 (2015).
 
Aulas, A., Caron, G., Gkogkas, C. G., Mohamed, N. V., Destroismaisons, L., Sonenberg, N., Leclerc, N., Parker, J. A. & Vande Velde, C. G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. J Cell Biol 209, 73-84, doi:10.1083/jcb.201408092 (2015).
 
2014
Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., Konicek, B. W., Graff, J. R., Tzinia, A. K., Lacaille, J. C. & Sonenberg, N. Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell reports 9, 1742-1755, doi:10.1016/j.celrep.2014.10.064 (2014).
 
Jung, H., Gkogkas, C. G., Sonenberg, N. & Holt, C. E. Remote control of gene function by local translation. Cell 157, 26-40, doi:10.1016/j.cell.2014.03.005 (2014).
 
Tahmasebi, S., Alain, T., Rajasekhar, V. K., Zhang, J. P., Prager-Khoutorsky, M., Khoutorsky, A., Dogan, Y., Gkogkas, C. G., Petroulakis, E., Sylvestre, A., Ghorbani, M., Assadian, S., Yamanaka, Y., Vinagolu-Baur, J. R., Teodoro, J. G., Kim, K., Yang, X. J. & Sonenberg, N. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell 14, 606-616, doi:10.1016/j.stem.2014.02.005 (2014).
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2013
Gkogkas, C. G. & Sonenberg, N. Translational control and autism-like behaviors. Cell Logist 3, e24551, doi:10.4161/cl.24551 (2013).

Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79, 712-724, doi:10.1016/j.neuron.2013.06.026 (2013).
 
Khoutorsky, A., Gkogkas, C. G.*, Yanagiya, A.*, Fabian, M. R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R. E., Mogil, J. S., Nader, K., Lacaille, J. C. & Sonenberg, N. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron 78, 298-311, doi:10.1016/j.neuron.2013.02.025 (2013).
 
Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A., Nevarko, T., Sonenberg, N. & Lacaille, J. C. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 1872-1886, doi:10.1523/JNEUROSCI.3264-12.2013 (2013).
 
Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., Major, F., Lasko, P., Ruggero, D., Nader, K., Lacaille, J. C. & Sonenberg, N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493, 371-377, doi:10.1038/nature11628 (2013).
 
2003-2012
Chua, J. J., Schob, C., Rehbein, M., Gkogkas, C. G., Richter, D. & Kindler, S. Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Sci Rep 2, 484, doi:10.1038/srep00484 (2012).
 
Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W. C. & Sonenberg, N. mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol 12, 235-245, doi:10.1038/nrm3083 (2011).
 
Gkogkas, C., Wardrope, C., Hannah, M. & Skehel, P. The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons. J Neurochem 117, 286-294, doi:10.1111/j.1471-4159.2011.07201.x (2011).
 
Gkogkas, C., Sonenberg, N. & Costa-Mattioli, M. Translational control mechanisms in long-lasting synaptic plasticity and memory. J Biol Chem 285, 31913-31917, doi:10.1074/jbc.R110.154476 (2010).
 
Bidinosti, M., Ran, I., Sanchez-Carbente, M. R., Martineau, Y., Gingras, A. C., Gkogkas, C., Raught, B., Bramham, C. R., Sossin, W. S., Costa-Mattioli, M., DesGroseillers, L., Lacaille, J. C. & Sonenberg, N. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell 37, 797-808, doi:10.1016/j.molcel.2010.02.022 (2010).
 
Rampakakis, E., Gkogkas, C., Di Paola, D. & Zannis-Hadjopoulos, M. Replication initiation and DNA topology: The twisted life of the origin. J Cell Biochem 110, 35-43, doi:10.1002/jcb.22557 (2010).
 
Gkogkas, C., Middleton, S., Kremer, A. M., Wardrope, C., Hannah, M., Gillingwater, T. H. & Skehel, P. VAPB interacts with and modulates the activity of ATF6. Hum Mol Genet 17, 1517-1526, doi:10.1093/hmg/ddn040 (2008).

Gkogkas, C. G.*, Vernikos, G. S.*, Promponas, V. J. & Hamodrakas, S. J. GeneViTo: visualizing gene-product functional and structural features in genomic datasets. BMC Bioinformatics 4, 53, doi:10.1186/1471-2105-4-53 (2003). *co-first